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There are also limitations, which should be considered before using this protocol (i.e., it is not indicated for individuals who have a contraindication for the use of a particular drug) (1). Further, while this protocol has a low mortality rate (i.e., the primary endpoint), safety profile of this protocol is limited (1). Nevertheless, this an attractive protocol for the use of corticosteroid therapy in the setting of CFS since it can be used with drugs that are available without a prescription (i.e., Tylenol, Metacam) (1). Thus, this protocol does not require the use of expensive medications that must be obtained in a pharmacological emergency; however, this should be considered in advance, as there can be a lack of available medications in this setting. Also, certain medications should be considered off-label to reduce the risk of overdose, since incidence overdose may increase due to a lack of familiarity with different preparations if they are used at different times during the course of treatment (24).
Finally, this protocol is not a definitive because it is limited to patients with CFS who have been clinically treated for 2 weeks or longer (2). This protocol may have different utility for populations.
REFERENCES:
1. Sargent JD, Gormley P, Zink J, et al. CFS. N Engl J Med. 2009;360:638-646. http://www.ncbi.nlm.nih.gov/pubmed/19843719
2. Sargent JD, Darnocai A, Zink J, et al. Intravenous dexamethasone for chronic fatigue syndrome. N Engl J Med. 2009;360:637-645. http://www.ncbi.nlm.nih.gov/pubmed/19031065
References and Notes
The Buy diazepam tablets online information provided in this brief is based on research in the U.S. Published studies are reported with authors' names by their initials or without author names and are identified by clinical trial identifier numbers. The most current information on clinical trials (and studies referenced in clinical trials) is available at www.ClinicalTrials.gov. Most reports from clinical trials not listed on ClinicalTrials.gov were published as abstracts from the meetings.
An abstract is published as a complete, separate paper when the abstract is filed with U.S. Health Resources and Services Administration, Public Health Service. An abstract is printed without authors' names.
A number of clinical trials have been published concerning the efficacy and safety of dexamethasone, including the multicenter (Linda Vista, Where to buy genuine diazepam CA) CD8/CD4 Trials and the National Institutes of Health-funded Multicenter Trial CD4/CD8 T-cells (NCT01157563). The reports from Linda Vista and Multicenter CD8/CD4 Trials have been abstracted and published as full reports in Clinical Infectious Diseases. The summary paper is available from the NIAID website [http://www.niaid.nih.gov/]. Two additional clinical trials, both of which were published.
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